Tadarise 2.5 mg, which contains Tadalafil, can be taken with or without food, as food does not significantly affect its absorption or effectiveness. However, here are a few important guidelines:

1. Avoid Heavy or Fatty Meals: While Tadarise 2.5 mg doesn't interact with food in a major way, it’s still best to avoid taking it with a heavy or high-fat meal. This is because such meals can slightly delay the absorption of the medication, which may lead to a slower onset of action.
   
2. Take at the Same Time Daily: If you're taking Tadarise 2.5 mg for daily use (as prescribed for continuous treatment), try to take it at the same time each day for consistency, regardless of meals.
   
3. Alcohol: It’s best to avoid excessive alcohol while using Tadarise, as it can increase the likelihood of side effects like dizziness or lowered blood pressure.
   

As always, follow your healthcare provider’s instructions on how to take this medication for optimal results. If you have specific concerns about food interactions or the timing of the dose, it’s a good idea to discuss it with your doctor.