When combining Tadarise 2.5 mg (which contains tadalafil) with other medications, it's important to consider the potential interactions and risks, as some medications may affect how tadalafil works or increase the risk of side effects.
Here are some general guidelines:

1. Avoid Nitrate Medications: Do not take tadalafil with nitrates (e.g., nitroglycerin or isosorbide), which are commonly prescribed for chest pain or heart problems. The combination can cause a dangerous drop in blood pressure.
   
2. Alpha-Blockers: Caution is needed if you're taking alpha-blockers (e.g., doxazosin, tamsulosin) for high blood pressure or prostate problems. Combining these with tadalafil can also lead to a significant drop in blood pressure.
   
3. Other Erectile Dysfunction Medications: Avoid using tadalafil in combination with other PDE5 inhibitors (like sildenafil or vardenafil), as it may increase the risk of side effects, including dizziness or prolonged erections.
   
4. Antifungal and Antibiotic Medications: Some antifungals (e.g., ketoconazole) and antibiotics (e.g., clarithromycin) can affect the breakdown of tadalafil in your body. If you're taking these, your doctor may adjust your tadalafil dose.
   
5. Other Conditions and Medications: If you're on medications for diabetes, blood pressure, or other cardiovascular conditions, always check with your healthcare provider before starting Tadarise 2.5mg to ensure there are no interactions.
   

To ensure safe use, it's always recommended to consult with your doctor or pharmacist before combining Tadarise 2.5 mg with any other medication. They can provide guidance based on your specific health situation and the medications you're taking.