Cenforce 150, like other medications containing sildenafil citrate, requires sexual stimulation to be effective due to its mechanism of action. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, and here’s how it works:
Nitric Oxide Release: When a man is sexually stimulated, the body releases nitric oxide (NO) in the erectile tissue of the penis. This is a natural response to sexual arousal.
cGMP Production: Nitric oxide activates the enzyme guanylate cyclase, which increases levels of cyclic guanosine monophosphate (cGMP). cGMP is a substance that relaxes the smooth muscles and widens the blood vessels in the penis, allowing increased blood flow.
Inhibition of PDE5: Sildenafil citrate, the active ingredient in Cenforce 150 mg, inhibits the enzyme PDE5. PDE5 is responsible for breaking down cGMP. By inhibiting PDE5, sildenafil ensures that cGMP levels remain elevated, leading to prolonged relaxation of smooth muscles and increased blood flow to the penis, which is necessary for achieving and maintaining an erection.
Without sexual stimulation, there is no release of nitric oxide, which means the cascade of events leading to the production of cGMP doesn't occur. Therefore, even though sildenafil is present in the system, it cannot facilitate an erection because the initial trigger (sexual arousal) is missing.