Combining Vigora Oral Jelly (which contains Sildenafil Citrate) with other medications can pose several risks, mainly due to potential interactions that can affect the efficacy of the medications or increase the risk of side effects. Here are some key considerations:

1. Nitrates: Combining Vigora with nitrates (used to treat angina or chest pain) can lead to a dangerous drop in blood pressure. This interaction can cause symptoms like dizziness, fainting, or even a heart attack. Nitrates include medications like nitroglycerin and isosorbide dinitrate.
   
2. Alpha-Blockers: Taking Vigora with alpha-blockers (used for high blood pressure or benign prostatic hyperplasia) can also cause a significant drop in blood pressure. This can result in dizziness, lightheadedness, or fainting, especially when standing up quickly.
   
3. Other ED Medications: Combining Vigora with other erectile dysfunction medications (such as Cialis, Levitra, or other Sildenafil-based products) can increase the risk of side effects like priapism (a prolonged erection) and cardiovascular issues.
   
4. Antifungal and Antibiotic Medications: Some antifungal and antibiotic medications can affect the metabolism of Vigora Oral Jelly, leading to higher levels of the drug in the bloodstream and increased risk of side effects. For example, ketoconazole and erythromycin are known to interact with Sildenafil.
   
5. HIV Protease Inhibitors: Medications used to treat HIV, such as ritonavir or saquinavir, can also interact with Sildenafil, increasing the risk of adverse effects. These drugs can inhibit the enzymes responsible for metabolizing Sildenafil, leading to higher drug levels.
   
6. Other Medications: Certain other medications can impact the effectiveness or safety of Vigora, including those affecting blood pressure, liver enzyme function, or causing similar side effects.
   

Always inform your healthcare provider of all the medications and supplements you are taking before starting Vigora Oral Jelly. Your healthcare provider can help manage potential interactions and adjust your treatment plan to ensure safety and effectiveness.