Tadarise 40 mg, which contains Tadalafil, can be taken with or without food. However, there are some considerations for optimal effectiveness and comfort:

1. Timing: Tadarise 40 mg is typically taken about 30 minutes to an hour before sexual activity. The medication can remain effective for up to 36 hours, so you don’t need to time it precisely around meals if you’re planning ahead.
   
2. With Food: While Tadarise 40 mg can be taken with food, it is best to avoid very fatty or heavy meals close to the time you take the medication. High-fat meals can delay the absorption of Tadalafil and potentially reduce its effectiveness.
   
3. Without Food: If you prefer, you can take Tadarise 40 mg on an empty stomach. This might lead to faster absorption and more predictable results.
   
4. Consistency: If you take Tadarise regularly (for daily use, under the guidance of a healthcare provider), it is generally advised to take it at the same time each day, regardless of meals.
   

If you experience any issues or side effects related to taking Tadarise with or without food, or if you have specific dietary concerns, consult with your healthcare provider for personalized advice. They can help you adjust your dosage or timing to better suit your needs and lifestyle.