Malegra DXT is a combination medication containing two active ingredients: Sildenafil citrate and Duloxetine. Sildenafil citrate is used to treat erectile dysfunction (ED), while Duloxetine is used to treat premature ejaculation (PE).

The time it takes for Malegra DXT to start working can vary from person to person. Typically, the Sildenafil component of Malegra DXT starts to take effect within 30 minutes to 1 hour after ingestion. It's absorbed into the bloodstream relatively quickly, and its effects on erectile function can last for about 4 to 6 hours.

Duloxetine, on the other hand, is an antidepressant that works by increasing the levels of serotonin and norepinephrine in the brain. Its effects on premature ejaculation may take longer to become noticeable compared to Sildenafil. It may take several days or weeks of regular use for Duloxetine to reach its maximum effectiveness for treating PE.

Overall, the combined effects of Sildenafil and Duloxetine in Malegra DXT may vary depending on individual factors such as metabolism, underlying health conditions, and other medications being taken. It's essential to follow the dosage instructions provided by a healthcare professional and give the medication sufficient time to work before expecting optimal results. Additionally, it's crucial to discuss any concerns or questions about Malegra DXT with a doctor or pharmacist.